This focus meeting brings together leading researchers in the field of advanced materials and interfaces to discuss recent progress and perspectives in the areas of quantum technologies, topological materials, unconventional superconductivity, topological surface states and their interplay with conventional orders. A central point will be prospects and grand challenges of topological physics and its real-world applications. The meeting will help to promote the topic, enlarge the community interest in its development, and contribute to ensuring the leading role of topological research in condensed matter physics and beyond.